cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse

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cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse.

Expression of the mouse caudal genes cdx4 and cdx2 is examined by use of lacZ reporter constructs expressed in transgenic mouse embryos. During early gastrulation, up to at least 8.5 days of development, reporter mRNA distributions are apparently similar to those of endogenous cdx mRNAs. By 8.25 to 8.8 days, cdx/lacZ protein activities have become distributed as posterior-to-anterior gradients ...

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We describe the expression pattern of the mouse Cdx-1 gene during early development, examined by both RNA and protein analyses. Cdx-1 expression began with the onset of the head process formation (day 7.5) in ectodermal and mesodermal cells of the primitive streak. Expression extended initially to the middle of the prospective hindbrain and subsequently regressed caudad to the spinal cord level...

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ژورنال

عنوان ژورنال: The International Journal of Developmental Biology

سال: 2005

ISSN: 0214-6282

DOI: 10.1387/ijdb.052021sg